Italian Sub Grilled Cheese

Featured in: Weeknight Dinners

This Italian Sub Grilled Cheese brings together classic Italian deli flavors in one indulgent, melty sandwich. Layer provolone, salami, and pepperoni between buttered bread with a zesty lettuce mixture featuring mayonnaise, red wine vinegar, and oregano. Grill until the bread turns golden and the cheese melts beautifully, creating that perfect grinder experience. Ready in just 20 minutes total, it's ideal for lunch or a satisfying main course. Customize with pepperoncini or hot giardiniera for extra kick.

Updated on Tue, 20 Jan 2026 14:03:00 GMT
Golden-brown Italian Sub Grilled Cheese slices show melted provolone and colorful meats, topped with tangy lettuce on a cutting board. Save
Golden-brown Italian Sub Grilled Cheese slices show melted provolone and colorful meats, topped with tangy lettuce on a cutting board. | stellarcrust.com

The smell of salami and pepperoni hitting a hot skillet takes me back to late nights working at my uncles sub shop. He taught me that the crunch of toasted bread matters just as much as whats inside. Now whenever I crave that grinder flavor without leaving my house, this sandwich is my go to. The way the provolone melts into the cured meats creates something entirely new.

My college roommate used to make these during exam week when we needed something substantial but comforting. The whole apartment would smell like toasted bread and savory cured meat. Even now, one bite brings back that feeling of huddling around a tiny stove, hungry and exhausted, taking that first satisfying crunch.

Ingredients

  • Italian bread: Sturdy enough to hold everything together without getting soggy, sourdough works beautifully too
  • Unsalted butter: Softened to room temperature so it spreads evenly and helps achieve that golden crust
  • Provolone cheese: Creates the melty foundation that binds all the meats together
  • Salami: Adds depth and that familiar cured meat flavor we all recognize from subs
  • Pepperoni: Brings a subtle heat and extra savory punch to every bite
  • Shredded iceberg lettuce: The crisp texture is essential for the signature sub experience
  • Mayonnaise and red wine vinegar: This combination makes a quick creamy tangy dressing
  • Dried oregano: The herbal note that makes everything taste distinctly Italian

Instructions

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Make the lettuce topping first:
Toss shredded lettuce with mayonnaise, red wine vinegar, oregano, salt and pepper until everything is evenly coated
Prep your bread:
Butter one side of each bread slice generously and think about which sides will face the hot pan
Build the layers:
Place two slices butter side down then layer provolone, salami and pepperoni on each
Add the crunch:
Spread that dressed lettuce over the meats before topping with the remaining bread slices butter side up
Get it golden:
Cook in a hot skillet for three to four minutes per side pressing gently until the cheese melts and the bread turns perfectly crispy
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Keeps spices within easy reach while cooking, helping you season dishes quickly during everyday meal prep.
Check price on Amazon
Two halves of a toasted Italian Sub Grilled Cheese reveal stacked salami and pepperoni beside crisp kettle chips and fresh tomato salad. Save
Two halves of a toasted Italian Sub Grilled Cheese reveal stacked salami and pepperoni beside crisp kettle chips and fresh tomato salad. | stellarcrust.com

This recipe became a staple in our house during rainy weekends when we wanted comfort food but something more exciting than ordinary grilled cheese. My kids now request it by name, calling it the fancy sub sandwich.

Bread Selection Secrets

After testing countless breads, I have learned that a sturdy Italian loaf with a tight crumb holds up best to all those juicy toppings. Sourdough adds a wonderful tang while still providing the necessary structure. Avoid ultra soft sandwich bread because it will turn mushy under all these hearty ingredients.

Meat Layering Strategy

Think about how the meat folds when you layer it, creating small pockets for the cheese to melt into. I have found that slightly overlapping the salami and pepperoni ensures every bite contains both flavors. The cured fats from these meats will render slightly and help crisp the bread from the inside out.

Perfect Pairings

A simple tomato salad with olive oil and salt cuts right through all the richness. Kettle chips add an extra crunch that somehow makes sense here. For a complete meal, serve with a light soup or some marinated vegetables on the side.

  • Keep your lettuce mixture chilled until the very last second
  • Let the sandwich rest for about a minute after cooking so the cheese sets slightly
  • Use a sharp knife to cut through all those layers cleanly
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Buttery crust on the Italian Sub Grilled Cheese oozes provolone, with lettuce topping peeking from the sides, served hot on a plate. Save
Buttery crust on the Italian Sub Grilled Cheese oozes provolone, with lettuce topping peeking from the sides, served hot on a plate. | stellarcrust.com

There is something magical about transforming a classic sub into a warm pressed sandwich while keeping all the beloved flavors intact.

Recipe FAQs

Can I use different bread for this sandwich?

Absolutely. While Italian bread or sturdy white sandwich bread works best, you can substitute whole wheat or sourdough for different flavors and textures. Just ensure your bread is sturdy enough to hold the fillings without falling apart during grilling.

How do I prevent the bread from burning while the cheese melts?

Use medium heat and cook for 3-4 minutes per side, pressing gently with a spatula. This allows the cheese to melt thoroughly while the bread achieves a golden-brown exterior. If your pan runs hot, reduce to medium-low heat.

What makes the lettuce mixture special?

The lettuce mixture combines shredded iceberg lettuce with mayonnaise, red wine vinegar, dried oregano, salt, and pepper. This creates a tangy, herbaceous topping that balances the rich meats and cheese with a fresh, slightly acidic note reminiscent of Italian deli flavors.

Can I make this sandwich vegetarian?

You can create a vegetarian version by omitting the salami and pepperoni, then adding roasted red peppers, artichoke hearts, or sun-dried tomatoes. Keep the provolone and lettuce mixture for that authentic Italian flavor profile.

What sides pair well with this sandwich?

Serve alongside kettle chips for a classic pairing, or offer a light tomato salad to complement the rich, savory sandwich. A simple green salad with vinaigrette also balances the meal nicely.

How can I add more heat to this sandwich?

Stir hot giardiniera or extra pepperoncini rings into the lettuce mixture, or add them directly between the meat and cheese layers. Start with a small amount and adjust to your heat preference.

Italian Sub Grilled Cheese

Melty sandwich combining Italian cold cuts, provolone cheese, and tangy lettuce topping grilled to golden perfection.

Time to Prep
10 minutes
Time to Cook
10 minutes
Overall Time
20 minutes
Recipe by Logan Smith


Skill Level Easy

Cuisine Italian-American

Makes 2 Portions

Diet Preferences None specified

What You'll Need

Bread & Dairy

01 4 slices Italian bread or sturdy white sandwich bread
02 2 tablespoons unsalted butter, softened
03 4 slices provolone cheese

Meats

01 6 slices salami
02 6 slices pepperoni

Lettuce Topping

01 1 cup shredded iceberg lettuce
02 2 tablespoons mayonnaise
03 1 tablespoon red wine vinegar
04 1 teaspoon dried oregano
05 Salt and freshly ground black pepper to taste

Optional Additions

01 2 tablespoons mild pepperoncini rings, drained
02 2 tablespoons thinly sliced red onion

How to Make It

Step 01

Prepare Lettuce Mixture: In a bowl, combine shredded lettuce, mayonnaise, red wine vinegar, oregano, salt, and pepper. Mix well and set aside.

Step 02

Butter Bread Slices: Lay out the bread slices and spread one side of each with softened butter.

Step 03

Layer Base Sandwich: Place two slices, buttered side down, on a work surface. Top each with 2 slices provolone, 3 slices salami, and 3 slices pepperoni.

Step 04

Add Optional Toppings: Spread pepperoncini rings and red onion slices over the meats and cheese if desired.

Step 05

Add Lettuce Mixture: Spread the prepared lettuce mixture evenly over the meats and cheese.

Step 06

Complete Sandwich: Top each sandwich with remaining bread slices, buttered side up.

Step 07

Grill Sandwich: Heat a large skillet or grill pan over medium heat. Place sandwiches in the pan and cook 3 to 4 minutes per side, pressing gently, until bread is golden brown and cheese is fully melted.

Step 08

Serve: Remove from heat, slice each sandwich in half diagonally, and serve immediately while hot.

Tools You Need

  • Skillet or grill pan
  • Spatula
  • Mixing bowl
  • Knife and cutting board

Allergy Info

Always review each ingredient for allergens, and ask a healthcare provider if you’re unsure.
  • Contains wheat from bread
  • Contains milk from cheese, butter, and mayonnaise
  • Contains eggs in mayonnaise, check specific brands
  • Contains pork from salami and pepperoni

Nutrition Info (per portion)

This nutrition information serves as a guideline. For health concerns, talk to a professional.
  • Energy: 540
  • Total Fat: 34 g
  • Carbohydrates: 35 g
  • Proteins: 24 g